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AboutAboutAbout APEXXNARMechanism of actionClinical programmeClinical programmeAPEXXNAR clinical study overviewAPEXXNAR adverse drug reactionsAdministration
Pneumococcal conjugate vaccines like APEXXNAR® are designed to deliver  long-lasting immunity1,2APEXXNAR first

Vaccinating with a pneumococcal conjugate vaccine first has been shown to enhance the immune response of a subsequent pneumococcal polysaccharide vaccine administered 1 year later. 

PPSV23 first

Conversely, vaccinating with a pneumococcal polysaccharide vaccine first followed by a conjugate 1 year later can diminish the immune response compared to the conjugate vaccine alone.

▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 for how to report adverse reactions.References:APEXXNAR® Summary of Product Characteristics. Froes F, Roche N, Blasi F. Pneumococcal vaccination and chronic respiratory diseases. Int J Chron Obstruct Pulmon Dis. 2017;12:3457-3468.ClinicalTrials.gov. Trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naïve adults. Available at https://clinicaltrials.gov/ct2/show/NCT03760146. Last Accessed: August 2022ClinicalTrials.gov. Trial to evaluate the safety and immunogenicity of 3 lots of 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naïve adults. Available at https://clinicaltrials.gov/ct2/show/NCT03828617. Last Accessed: August 2022ClinicalTrials.gov. Trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal vaccine in adults 65 years of age or older with prior pneumococcal vaccination. Available at https://clinicaltrials.gov/ct2/show/NCT03835975. Last Accessed: August 2022About Study overview

APEXXNAR was evaluated for safety and immunogenicity across a diverse patient population.1,3-5

 Review the data Loading View Summary of Product Characteristics  Apexxnar® Loading Prevenar 13® Loading Patient profiles

See why certain patients may be at greater risk for pneumococcal disease.7

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Legal Category: S1A
Further information is available upon request

PP-PNR-IRL-0015 Date of Preparation: August 2022

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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