A once-daily oral treatment with flexible dosing to manage adverse reactions1

For special warnings and precautions for use, please see the LORVIQUA SmPC.

  • Treatment with LORVIQUA should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.1
  • Detection of ALK-positive NSCLC is necessary for selection of patients for treatment with LORVIQUA 1
  • LORVIQUA should be swallowed whole, with or without food—never chewed, crushed, or split1
  • LORVIQUA is contraindicated in patients taking strong CYP3A4/5 inducers concomitantly* and in those with hypersensitivity to LORVIQUA or any of the excipients of LORVIQUA1
  • For patients taking LORVIQUA, alternative concomitant medicinal products with less potential to inhibit CYP3A4/5 should be considered1,*
  • Patients must avoid grapefruit products while taking LORVIQUA1
  • There are specific recommendations for dose modifications related to particular ARs1


*Please refer to the LORVIQUA SmPC for recommendations regarding the use of CYP3A4/5 inducers and CYP3A4/5 inhibitors.AR=adverse reaction; AV=atrioventricular; CNS=central nervous system; CYP3A4/5=cytochrome P450 3A4/5; ILD=interstitial lung disease; SmPC=Summary of Product Characteristics.ReferencesReference:

Pfizer. LORVIQUA (lorlatinib) Summary of Product Characteristics. 

Dosing & Therapy Management
LORVIQUA safety profile
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