Getting ready

• Wash and dry your hands
• Use the pen straight from the refrigerator or leave it at room temperature for up to 30 minutes for a more comfortable injection

Choose and clean your injection site

• Injection should be given in the abdomen (belly), thighs, buttocks, or upper arms
• Select a different site for each injection
• Do not inject into bony areas, areas that are bruised, red, sore, or have scars or skin conditions
• Clean the injection site with an alcohol swab and let dry. Do not touch injection site after cleaning

Prepare your injection

• Pull off the pen cap and set it aside for after the injection. Check that the medicine is colorless to slightly light yellow and is free of flakes or particles
• Take a new needle and pull off its protective paper. Attach a new needle for each injection
• Pull off the outer needle cover. Set it aside for later to help remove the needle
• Pull off the inner needle cap. Throw away inner needle cap in a sharps container

Set your prescribed dose

• Turn the knob to set your dose; dose knob turns 0.5 mg at a time for the NGENLA 60-mg pen and 0.2 mg at a time for the NGENLA 24-mg pen
• Check the dose window to make sure you have set the correct dose
• If your dose is more than 30 mg when using the NGENLA 60-mg pen, or more than 12 mg when using the NGENLA 24-mg pen, you will need more than 1 injection. Use a new needle for each injection

Inject your dose

• Hold the pen so you can see the numbers in the dose window
• Insert the needle straight into your skin
• Press the injection button until it can’t go down any further and “0” is displayed in the dose window. Hold the button down for 10 seconds, then let go of the injection button and remove the pen from the injection site by pulling the needle straight out

Finish up

• Carefully replace the outer needle cover
• Unscrew the capped needle and dispose of it in a sharps container
• Do not reuse needles
• Replace the pen cap. If there is any medicine left, store it in the refrigerator between uses

If setting up the first use of new pen:

• Turn the dose knob to 1.0 for the 60-mg pen; for the 24-mg pen, set dose knob to 0.4
• Hold the pen with the needle pointing up. Tap cartridge holder gently to float any air bubbles to the top
• Press the injection button until it cannot go any further and you see “0” in the dose window. If liquid appears at needle tip, the pen is set up. If liquid has not appeared, repeat first-use steps