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TALZENNA MoA

Talzenna MoA

gBRCA testing

Identifying patients

Guidelines

Study design

Baseline characteristics

Efficacy & Safety

TALZENNA efficacy

Primary endpoint & subgroup analysis

Secondary endpoints: ORR

Secondary endpoint: OS

Exploratory endpoints: DoR & TTR

TALZENNA safety

Safety and tolerabillity

Adverse events

Patient-reported outcomes with TALZENNA

Patient-reported outcomes

GHS/QoL

Breast symptoms

Dosing

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Patient Profiles

Prescribing Information

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Elevate

Personalising Breast Cancer Treatment

Understanding and Optimising PARP Inhibitors for mBC

PARP Inhibitors in mBC: the role of Real World Evidence

Now you can give them more

TALZENNA^® is indicated as monotherapy for the treatment of adult patients with germline BRCA1/2-mutations, who have HER2-negative locally advanced or metastatic breast cancer. Patients should have been previously treated with an anthracycline and/or taxane in the (neo)adjuvant, locally advanced or metastatic setting unless patients were not suitable for these treatments. Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine-based therapy, or be considered unsuitable for endocrine-based therapy.¹

Please see full Prescribing Information and Patient Information.

TALZENNA^® is a proven alternative to chemotherapy* – with greater efficacy in a convenient, once-daily oral dose¹

TALZENNA^®significantly prolonged median progression-free survival (PFS) vs chemotherapy: 8.6 vs 5.6 months (HR=0.54 [95% CI: 0.41-0.71]; P<0.0001)¹

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Improved patient-reported outcomes

Significant improvements in GHS/QoL and breast symptoms²

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Manageable safety profile

AEs were manageable with a low discontinuation rate¹

Review safety

Convenient, once-daily oral dosing

One dose once a day with or without food¹

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AE=adverse event; BRCA=breast cancer susceptibility gene; CI=confidence interval; GHS=global health status; HER2-=human epidermal growth factor receptor 2 negative; HR=hazard ratio; QoL=quality of life.

*Capecitabine, eribulin, gemcitabine, or vinorelbine.

References:

TALZENNA^® Summary of Product Characteristics.

Litton JK, Hurvitz SA, Mina LA, et al. Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: ﬁnal overall survival results from the EMBRACA trial. Ann Oncol. 2020;31(11):1526-1535.

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PP-TAL-IRL-0106 May 2024

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This site is intended only for healthcare professionals resident in the Republic of Ireland. If you are a member of the public wishing to access information on a specific medicine, please visit https://www.medicines.ie

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PP-UNP-IRL-0891. February 2025

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PP-UNP-IRL-0891. February 2025