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AboutTALZENNA MoATalzenna MoAgBRCA testingIdentifying patientsGuidelinesStudy designStudy designBaseline characteristicsEfficacy & SafetyTALZENNA efficacyPrimary endpoint & subgroup analysisSecondary endpoints: ORRSecondary endpoint: OSExploratory endpoints: DoR & TTRTALZENNA safetySafety and tolerabillityAdverse eventsHaematologic/Nonhaematologic AEsPatient-reported outcomes with TALZENNAPatient-reported outcomesGHS/QoLBreast symptomsDosingDosingDose recommendation and special populationsDose modifications/managementPatient ProfilesSupport & ResourcesSupport & ResourcesMaterialsVideosElevateElevatePersonalising Breast Cancer TreatmentUnderstanding and Optimising PARP Inhibitors for mBCPARP Inhibitors in mBC: the role of Real World Evidence
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TALZENNA is indicated as monotherapy for the treatment of adult patients with germline BRCA1/2-mutations, who have HER2-negative locally advanced or metastatic breast cancer. Patients should have been previously treated with an anthracycline and/or taxane in the (neo)adjuvant, locally advanced or metastatic setting unless patients were not suitable for these treatments. Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine-based therapy, or be considered unsuitable for endocrine-based therapy.1

Please see full Prescribing Information and Patient Information.

TALZENNA is a proven alternative to chemotherapy* – with greater efficacy in a convenient, once-daily oral dose1

TALZENNA significantly prolonged median progression-free survival (PFS) vs chemotherapy: 8.6 vs 5.6 months (HR=0.54 [95% CI: 0.41-0.71]; P<0.0001)1

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Improved patient-reported outcomes

Significant improvements in GHS/QoL and breast symptoms2

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Manageable safety profile 

AEs were manageable with a low discontinuation rate1

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Convenient, once-daily oral dosing

One dose once a day with or without food1

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AE=adverse event; BRCA=breast cancer susceptibility gene; CI=confidence interval; GHS=global health status; HER2-=human epidermal growth factor receptor 2 negative; HR=hazard ratio; QoL=quality of life.*Capecitabine, eribulin, gemcitabine, or vinorelbine.
References:TALZENNA Summary of Product Characteristics. Litton JK, Hurvitz SA, Mina LA, et al. Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial. Ann Oncol. 2020;31(11):1526-1535.
This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of full SmPC for how to report adverse reactions.

Legal Category: S1A 
Further information is available upon request

PP-TAL-IRL-0059 April 2023

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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