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cIAI/cUTI, including pyelonephritis2
cUTI, including pyelonephritis4
The efficacy of ZAVICEFTA (ceftazidime–avibactam) for the treatment of adult patients with bacteraemia in association with HAP/VAP, cIAI or cUTI is supported by data from a subset of 101 adult patients across the Phase III clinical trial programme5†
Data support the use of ZAVICEFTA in adult patients with limited treatment options including in:6–20
REPRISE Phase III trial:
Ceftazidime-resistant Enterobacterales (most commonly E. coli or K. pneumoniae) and P. aeruginosa
REPROVE Phase III trial:
Predominantly K. pneumoniae and P. aeruginosa including some ceftazidime-resistant strains
100 patients (28%) had ≥1 ceftazidime-resistant isolate
RECAPTURE Phase III trial:
Predominantly E. coli and K. pneumoniae including some ceftazidime-resistant strains
RECLAIM Phase III trial:
E. coli, K. pneumoniae and P. aeruginosa including some ceftazidime-resistant strains
417 patients (40%) had polymicrobial infection at baseline
In this post-hoc analysis†, ZAVICEFTA showed favourable clinical and microbiological response rates in adult patients with bacteraemia‡
associated with HAP/VAP, cIAI or cUTI.5,21
E. coli (69%); K. pneumoniae (21%); P. aeruginosa (17%).
Acute pyelonephritis (47%); VAP (15%).
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PP-UNP-IRL-0176. January 2023