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Clinical efficacy & safetyPALOMA-2Trial design overviewPatient baseline characteristicsProgression-free survival (primary endpoint)Overall survival (secondary endpoint)Tumour control (secondary endpoint)PALOMA-2 summaryPALOMA-3Trial design overviewPatient baseline characteristicsProgression-free survival (primary endpoint)Overall survival (secondary endpoint)Tumour control (secondary endpoint)SafetySafety overviewPooled laboratory abnormalitiesPALOMA-2 AEsPALOMA-3 AEsSelected safety featuresIBRANCE long-term safetyGI and liver toxicitiesEffect of IBRANCE on QTc intervalElderly patientsVisceral disease patientsDose reduction effect on efficacyRW evidenceValue of RWEWhat is real-world evidence?What is the value of RWE?P-REALITY and P-REALITY XP-REALITY OverviewP-REALITY OS and rwPFSP-REALITY X OverviewP-REALITY X OS and rwPFSIRISIRIS OverviewIRIS PFS and OSPOLARIS POLARIS OverviewPOLARIS Patient-Reported OutcomesMADELINEMADELINE OverviewMADELINE Patient CharacteristicsMADELINE Patient-Reported OutcomesPalomAGEPalomAGE OverviewRWE in Older Patients with mBCP-VERIFYP-VERIFY StudyPatient-reported outcomesPALOMA-2: FACT-B scoresPALOMA-3: EORTC QLQ-C30 scoresPALOMA-3: Time to deterioration in pain symptomsDosingRecommended dosing scheduleRecommended dose modifications for AEsMonitoringOne scheduled monitoring provisionPrescribing Information ResourcesMaterials

IBRANCE is indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer:

  • in combination with an aromatase inhibitor;
  • in combination with fulvestrant in women who have received prior endocrine therapy

In pre- or peri-menopausal women, the endocrine therapy should be combined with a luteinising hormone-releasing hormone (LHRH) agonist.1

Please see Full Prescribing lnformation and Patient lnformation

 RCT PALOMA 2 & PALOMA 3

PALOMA was the first clinical trial programme to explore how a CDK4/6 inhibitor could benefit women with HR+/HER2- mBC23

 Explore PALOMA 2 & PALOMA 3 RWE complements RCTs

With RCT data,15-19 IBRANCE RWE20-22 can help improve understanding of outcomes in patients with HR+/HER2- mBC and help you to better support your patients

 Learn more about RWE Healthcare Professional Resources

Please note the materials are intended for healthcare professionals to effectively support patient care.

 Click here for HCP Resources Provide your patients with proven strength

A broad range of women with HR+/HER2- mBC may benefit from IBRANCE combination therapy.1-9 IBRANCE is the first CDK4/6 inhibitor supported by data from clinical trials1-4 and real-world evidence.5-7

 Find out more TitleOver 838,000 patients have been prescribed IBRANCE since FDA approval in 201524 Resources Find out more
CDK = cyclin-dependent kinase; FDA = Food and Drug Administration; HR+/HER2- = hormone receptor-positive, human epidermal growth factor 2-negative; mBC = metastatic breast cancer;  RCT = randomised controlled trial; RWE = real-world evidence.References:1. IBRANCE® (palbociclib) Summary of Product Characteristics. 
2. Rugo HS, et al. Breast Cancer Res Treat 2019;174:719–729; 
3. Bell T, et al. Curr Med Res Opin 2016;32:959–965.
4. Cristofanilli M, et al. Eur J Cancer 2018;104:21–31.
5. Darden C, et al. Future Oncol 2019;15:141–150.
6. Harbeck N, et al. Ann Oncol 2016;27:1047–1054. 
7. Megari K. Health Psychol Res 2013;1:e27.
8. Mycock K, et al. Clin Ther 2022;44:1588–1601.
9. Palmieri C, et al. Poster 1710. Presented at ESMO, 16–21 September 2021, virtual symposium.
10. Richardson D, et al. Breast Cancer Res Treat 2021;187:113–124.
11. Rugo HS, et al. Ann Oncol 2018;29:888–894.
12. Rugo HS, et al. NPJ Breast Cancer 2022;8:114.
13. Tibau A, et al. Ther Adv Med Oncol 2023;15:1–14. 
14. Turner N, et al. N Engl J Med 2018;379:1926–1936.
15. Finn RS, et al. N Engl J Med. 2016;375(20):1925-1936.
16. Rugo H, et al. Breast Cancer Res Treat. 2019;174(3):719-729.
17. Cristofanilli M, et al. Lancet Oncol. 2016;17(4):425-439.
18. Cristofanilli M, et al. ASCO 2021; Oral presentation 1000.
19. Rugo HS, et al. Oncologist. 2021;26(8):e1339-e1346.
20. DeMichele A, et al. Breast Cancer Res. 2021;23:37.
21. Taylor-Stokes G, et al. Breast. 2019;43:22-27.
22. Waller J, et al. J Glob Oncol. 2019;5:JGO1800239.
23. McCain J. P T. 2015;40(8):511-520.
24. IBRANCE data on file. Patients prescribed IBRANCE worldwide.

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