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The PALOMA-3 OS final analysis of IBRANCE in combination with fulvestrant in 1st line or later demonstrated a numerical difference in favour of IBRANCE in combination with fulvestrant vs placebo + fulvestrant that did not reach statistical significance1,2
The difference in median OS with IBRANCE in combination with fulvestrant (not statistically significant)1 was similar to the improvement in mPFS previously seen with the addition of IBRANCE to fulvestrant in PALOMA-31,3
Adapted from IBRANCE SmPC2 and Turner NC, et al. 2018.1
Data cut-off date: April 13, 2018.
The final updated non-prespecified OS analysis demonstrated a numerical difference in mOS in favor of IBRANCE + fulvestrant, at >6 years median follow-up.⁴
Data cut-off date: August 17, 2020.
See PALOMA-2 overall survival data
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