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Clinical efficacy & safetyPALOMA-2Trial design overviewPatient baseline characteristicsProgression-free survival (primary endpoint)Overall survival (secondary endpoint)Tumour control (secondary endpoint)PALOMA-2 summaryPALOMA-3Trial design overviewPatient baseline characteristicsProgression-free survival (primary endpoint)Overall survival (secondary endpoint)Tumour control (secondary endpoint)SafetySafety overviewPooled laboratory abnormalitiesPALOMA-2 AEsPALOMA-3 AEsSelected safety featuresIBRANCE long-term safetyGI and liver toxicitiesEffect of IBRANCE on QTc intervalElderly patientsVisceral disease patientsDose reduction effect on efficacyRW evidenceValue of RWEWhat is real-world evidence?What is the value of RWE?P-REALITY and P-REALITY XP-REALITY OverviewP-REALITY OS and rwPFSP-REALITY X OverviewP-REALITY X OS and rwPFSIRISIRIS OverviewIRIS PFS and OSPOLARIS POLARIS OverviewPOLARIS Patient-Reported OutcomesMADELINEMADELINE OverviewMADELINE Patient CharacteristicsMADELINE Patient-Reported OutcomesPalomAGEPalomAGE OverviewRWE in Older Patients with mBCPatient-reported outcomesPALOMA-2: FACT-B scoresPALOMA-3: EORTC QLQ-C30 scoresPALOMA-3: Time to deterioration in pain symptomsDosingRecommended dosing scheduleRecommended dose modifications for AEsMonitoringOne scheduled monitoring provision ResourcesMaterials
IRIS overview

IRIS (IBRANCE Real World Insights) is an observational retrospective chart review in >2700 patients with HR+/HER2- ABC/mBC treated with IBRANCE combination therapy across 12 countries in North and South America, and Europe.1-5

Results have already been reported for some countries, including the US, Argentina, Canada
and 9 European countries.1-5

IRIS includes a diverse population of 2784 patients receiving IBRANCE in combination with
an aromatase inhibitor or IBRANCE plus fulvestrant.1-5

Select baseline patient characteristics1-5

Adapted from Taylor-Stokes G, et al. 2019;¹ Mycock K, et al. 2021;² Zhan L, et al. 2020;³ Waller J, et al. 2019;⁴ Mycock K, et al. 2020.⁵

Observational retrospective analyses are designed to evaluate associations among variables and cannot establish causality. Observational retrospective analyses are not intended for direct comparison with clinical trials.Observational retrospective analyses are designed to evaluate associations among variables and cannot establish causality. Observational retrospective analyses are not intended for direct comparison with clinical trials.Explore More IRIS survival outcomes Explore more Loading P-REALITY
overview Explore more Loading P-REALITY X overview Explore more LoadingReferencesABC = advanced breast cancer; AI = aromatase inhibitor; ECOG PS = Eastern Cooperative Oncology Group performance status; HCP = healthcare provider; HR+/HER2- = hormone receptor-positive, human epidermal growth factor receptor 2-negative; mBC = metastatic breast cancer; NR = not reported. References:Taylor-Stokes G, et al. Breast. 2019;43:22-27. Mycock K, et al. Curr Oncol. 2021;28:678-688. Zhan L, et al. MBCC 2020; Poster 30. Waller J, et al. J Glob Oncol. 2019;5:JGO1800239. Mycock K, et al. EBCC 2020; Poster 510. IRIS
IBRANCE Summary of Product Characteristics Product Characteristics Loading

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