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Over 10 years, clinicians’ experience of INLYTA® has demonstrated the safety and tolerability profile of INLYTA® observed in clinical trials.1–5
The short half-life of INLYTA® ensures that it is cleared more quickly following dose interruptions/discontinuations:1,2
AEs |
INLYTA® (n=359) | Sorafenib (n=355) | ||
---|---|---|---|---|
All grades (%) | ≥ Grade 3 (%) | All grades (%) | ≥ Grade 3 (%) | |
Diarrhoea | 55 | 11 | 53 | 7 |
Hypertension | 40 | 16 | 29 | 11 |
Fatigue | 39 | 11 | 32 | 5 |
Decreased appetite | 34 | 5 | 29 | 4 |
Nausea | 32 | 3 | 22 | 1 |
Dysphonia | 31 | 0 | 14 | 0 |
Hand–foot syndrome | 27 | 5 | 51 | 16 |
Weight decreased | 25 | 2 | 21 | 1 |
Vomiting | 24 | 3 | 17 | 1 |
Asthenia | 21 | 5 | 14 | 3 |
Constipation | 20 | 1 | 20 | 1 |
Rash | 13 | <1 | 32 | 4 |
Alopecia | 4 | 0 | 32 | 0 |
Hypothyroidism | 19 | <1 | 8 | 0 |
Cough | 15 | 1 | 17 | 1 |
Mucosal inflammation | 15 | 1 | 12 | 1 |
Arthralgia | 15 | 1 | 11 | 1 |
Stomatitis | 15 | 1 | 12 | <1 |
For some patients, taking a short break (e.g. 1–2 days) before restarting INLYTA® may help AEs to resolve quickly.1,6
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Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
Adverse events should also be reported to Pfizer Medical Information on 1800 633 363
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PP-UNP-IRL-0176. January 2023