LORVIQUA was evaluated as a first-line treatment option in the CROWN study. CROWN was a global, randomised, open-label, multicentre, Phase 3 trial of LORVIQUA vs crizotinib in patients with previously untreated, ALK-positive, locally advanced or metastatic NSCLC (N=296).1,2
Crizotinib was selected for the comparator arm because it was the standard-of-care first-line treatment at the time of trial initiation.2
Approximately 26% of patients in both the LORVIQUA and crizotinib treatment arms had brain metastases at baseline.2
Characteristic |
LORVIQUA (n=149) |
Crizotinib (n=147) |
---|---|---|
Age, years | ||
Mean (SD)d | 59.1 (±13.1) | 55.6 (±13.5) |
Median (IQR) | 61 (51-69) | 56 (45-66) |
Sex, n (%) | ||
Female | 84 (56) | 91 (62) |
Male | 65 (44) | 56 (38) |
Race or ethnic group, n (%)e | ||
White | 72 (48) | 72 (49) |
Asian | 65 (44) | 65 (44) |
Black | 0 | 1 (1) |
Missing | 12 (8) | 9 (6) |
Smoking status, n (%)f | ||
Never smoked | 81 (54) | 94 (64) |
Previous smoker | 55 (37) | 43 (29) |
Current smoker | 13 (9) | 9 (6) |
ECOG PS, n (%)g | ||
0 | 67 (45) | 57 (39) |
1 | 79 (53) | 81 (55) |
2 | 3 (2) | 9 (6) |
Characteristic | LORVIQUA (n=149) |
Crizotinib (n=147) |
---|---|---|
Current stage of disease, n (%) | ||
IIIA | 1 (1) | 0 |
IIIB | 12 (8) | 8 (5) |
IV | 135 (91) | 139 (95) |
Otherh | 1 (1) | 0 |
Histologic type, n (%) | ||
Adenocarcinoma | 140 (94) | 140 (95) |
Adenosquamous carcinoma | 6 (4) | 5 (3) |
Large cell carcinoma | 0 | 1 (1) |
Squamous cell carcinoma | 3 (2) | 1 (1) |
Use of previous anticancer drug therapy, n (%)i | ||
12 (8) | 9 (6) | |
Previous brain radiotherapy, n (%) | ||
9 (6) | 10 (7) | |
Brain metastases at baseline, n (%) | ||
38 (26) | 40 (27) |
Pfizer. LORVIQUA (lorlatinib) Summary of Product Characteristics.
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PP-UNP-IRL-0784. June 2024