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AboutTALZENNA MoATalzenna MoAgBRCA testingIdentifying patientsGuidelinesStudy designStudy designBaseline characteristicsEfficacy & SafetyTALZENNA efficacyPrimary endpoint & subgroup analysisSecondary endpoints: ORRSecondary endpoint: OSExploratory endpoints: DoR & TTRTALZENNA safetySafety and tolerabillityAdverse eventsHaematologic/Nonhaematologic AEsPatient-reported outcomes with TALZENNAPatient-reported outcomesGHS/QoLBreast symptomsDosingDosingDose recommendation and special populationsDose modifications/managementPatient ProfilesSupport & ResourcesSupport & ResourcesMaterials
TALZENNA is a targeted treatment that leads to cancer cell death via PARP inhibition and trapping1*PARP inhibitionPreclinical studies have shown:
  • gBRCA-mutated tumor cells depend on PARP enzymes to repair damaged DNA during proliferation1
  • TALZENNA inhibits PARP activity, which can disrupt DNA repair and lead to tumor cell death1-3
PARP trappingPreclinical studies have shown:
  • TALZENNA provides highly potent PARP trapping, which prevents DNA repair and replication1,3-5
BRCA=breast cancer susceptibility gene; DSBs=double-strand breaks; gBRCA=germline breast cancer susceptibility gene; MOA=mechanism of action; PARP=poly (ADP-ribose) polymerase; PFS=progression-free survival; SSBs=single-strand breaks.*Talazoparib can also affect healthy cells.
 Explore more gBRCA testing
References:Gavande NS, VanderVere-Carozza PS, Hinshaw HD, et al. DNA repair targeted therapy: the past or future of cancer treatment? Pharmacol Ther. 2016;160:65-83.Iglehart JD, Silver DP. Synthetic lethality—a new direction in cancer-drug development. N Engl J Med. 2009;361(2):189-191. van Wietmarschen N, Nussenzweig A. Mechanism for synthetic lethality in BRCA-deficient cancers: no longer lagging behind. Mol Cell. 2018;71(6):877-878.Lee J-m, Ledermann JA, Kohn EC. PARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2014;25(1):32-40.Murai J, Huang SN, Renaud A, et al. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther. 2014;13(2):433-443.TALZENNA Summary of Product Characteristics. Cardoso F, Paluch-Shimon S, Senkus E, et al. 5th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 5). Ann Oncol. 2020;31(12):1623-1649.
​​​​​​​▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of full SmPC for how to report adverse reactions.

Legal Category: S1A 
Further information is available upon request

PP-TAL-IRL-0059 April 2023
About Significantly longer PFS 

Superior to chemotherapy in delaying disease progression6 

 See the dataLoading gBRCA testing

Test early for gBRCA mutations to inform treatment planning7

 View guidelines
TALZENNA Summary of Product Characteristics Product CharacteristicsLoading

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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