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AboutTALZENNA MoATalzenna MoAgBRCA testingIdentifying patientsGuidelinesStudy designStudy designBaseline characteristicsEfficacy & SafetyTALZENNA efficacyPrimary endpoint & subgroup analysisSecondary endpoints: ORRSecondary endpoint: OSExploratory endpoints: DoR & TTRTALZENNA safetySafety and tolerabillityAdverse eventsPatient-reported outcomes with TALZENNAPatient-reported outcomesGHS/QoLBreast symptomsDosingDosingDose recommendation and special populationsDose modifications/managementPatient ProfilesPrescribing InformationSupport & ResourcesSupport & ResourcesMaterialsElevatePersonalising Breast Cancer TreatmentUnderstanding and Optimising PARP Inhibitors for mBCPARP Inhibitors in mBC: the role of Real World Evidence
Selected baseline characteristics1,2​​​​​​​
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  TALZENNA® (n=287) Chemotherapy* (n=144)
Demographics
Age, median (range), y 45 (27.0-84.0) 50 (24.0-88.0)
<50 y, No. (%) 182 (63.4) 67 (46.5)
50 y to <65 y, No. (%) 78 (27.2) 67 (46.5)
≥65 y, No. (%) 27 (9.4) 10 (6.9)
Female, No. (%) 283 (98.6) 141 (97.9)
Clinical status
Stage of BC    
Locally advanced, No. (%) 15 (5.2) 9 (6.2)
Metastatic, No. (%) 271 (94.4) 135 (93.8)
ECOG PS 0/1/2, (%) 53.3/44.3/2.1 58.3/39.6/1.4
Measurable disease by investigator, No. (%) 219 (76.3) 114 (79.2)
History of CNS metastases, No. (%) 43 (15.0) 20 (13.9)
Visceral disease, No. (%) 200 (69.7) 103 (71.5)
Disease-free interval (initial diagnosis to ABC) <12 months, No. (%) 108 (37.6) 42 (29.2)
Hormone receptor status, No. (%)
TNBC 130 (45.3) 60 (41.7)
HR+/HER2- 157 (54.7) 84 (58.3)
BRCA status by central or local laboratory assessment, No. (%)†
BRCA1-mutation positive 133 (46.3) 63 (43.8)‡
BRCA2-mutation positive 154 (53.7) 81 (56.3)‡
Prior cytotoxic regimens for ABC, No. (%)
0 111 (38.7) 54 (37.5)
1 107 (37.3) 54 (37.5)
2 57 (19.9) 28 (19.4)
3 11 (3.8) 8 (5.6)
≥4 1 (0.3) 0 (0.0)
Number of patients who received following prior therapies, No. (%)
Taxane 262 (91.3) 130 (90.3)
Anthracycline 243 (84.7) 115 (79.9)
Platinum 46 (16.0) 30 (20.8)
Adapted from TALZENNA® SmPC, and Litton et al. N Engl J Med. 2018.2
ABC=advanced breast cancer; BC=breast cancer; BRCA=breast cancer susceptibility gene; CNS=central nervous system; ECOG PS=Eastern Cooperative Oncology Group performance status; gBRCA=germline breast cancer susceptibility gene; GHS=global health status; HER2-=human epidermal growth factor receptor 2 negative; HR+=hormone receptor-positive; PFS=progression-free survival; QoL=quality of life; TNBC=triple-negative breast cancer.Capecitabine, eribulin, gemcitabine, or vinorelbine. Patients had a deleterious or suspected deleterious gBRCA mutation detected using a clinical trial assay.1Percentages do not add up to 100 due to rounding. Explore more Efficacy & safety
References:TALZENNA® Summary of Product Characteristics. Litton JK, Rugo HS, Ettl J, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation. N Engl J Med. 2018;379(8):753-763. Litton JK, Hurvitz SA, Mina LA, et al. Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial. Ann Oncol. 2020;31(11):1526-1535.

Legal Category: S1A 
Further information is available upon request

PP-TAL-IRL-0106 May 2024
About Significantly longer PFS 

Superior to chemotherapy in delaying disease progression1 

 See the data  Improved patient-reported outcomes

Significant improvements in GHS/QoL and breast symptoms3​​​​​​​

 See the results
TALZENNA Summary of Product Characteristics Product CharacteristicsLoading

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