This site is intended only for healthcare professionals resident in the Republic of Ireland

Search

Menu

Close

Sign in or RegisterLog out
Our medicinesTherapy areasExplore contentExplore contentMaterialsVideosPodcastsLet’s connectLet's connectContact usSign up

Menu

Close

AboutTALZENNA MoATalzenna MoAgBRCA testingIdentifying patientsGuidelinesStudy designStudy designBaseline characteristicsEfficacy & SafetyTALZENNA efficacyPrimary endpoint & subgroup analysisSecondary endpoints: ORRSecondary endpoint: OSExploratory endpoints: DoR & TTRTALZENNA safetySafety and tolerabillityAdverse eventsPatient-reported outcomes with TALZENNAPatient-reported outcomesGHS/QoLBreast symptomsDosingDosingDose recommendation and special populationsDose modifications/managementPatient ProfilesPrescribing InformationSupport & ResourcesSupport & ResourcesMaterialsElevatePersonalising Breast Cancer TreatmentUnderstanding and Optimising PARP Inhibitors for mBCPARP Inhibitors in mBC: the role of Real World Evidence
Significant overa​​​​​​​ll improvement in GHS/QoL vs chemotherapy1*†​​​​​​​

TALZENNA® was associated with significant overall improvement from baseline† in GHS/QOL and delayed time to definitive clinically meaningful detioration‡§ in GHS/QOL vs. chemotherapy.

Estimated overall mean change from baseline in GHS/QoL: Prespecified exploratory:‡ Adapted from Litton et al. Ann Oncol. 2020.1

PROs were included as exploratory endpoints in this open-label study; analyses were prespecified and adjustments for multiplicity were not made. No efficacy conclusions can be made from these data.2​​​​​​​

Significantly delayed time to definitive clinically meaningful deterioration§ in GHS/QoL vs chemotherapy1ll Time to definitive clinically meaningful deterioration of GHS/QoL: Prespecified exploratory endpoint  Adapted from Litton et al. Ann Oncol. 2020.1

PROs were included as exploratory endpoints in this open-label study; analyses were prespecified and adjustments for multiplicity were not made. No efficacy conclusions can be made from these data.2

AE=adverse event; Cl=confidence interval; GHS=global health status; ITT=intent-to-treat; PFS=progression-free survival; PROs=patient-reported outcomes; QoL=quality of life.Conducted in the PRO-evaluable population, defined as those in the ITT population with a baseline assessment and at least 1 post-baseline assessment. Capecitabine, eribulin, gemcitabine, or vinorelbine. Results from longitudinal repeated measures analyses (mixed-effects model). Defined as the time from randomization to the first observation with a ≥10-point decrease and no subsequent observations with a <10-point decrease from baseline. Results analyzed with the use of a stratified log-rank test, summarized with the use of Kaplan-Meier methods. Explore more Breast symptoms
References:Litton JK, Hurvitz SA, Mina LA, et al. Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial. Ann Oncol. 2020;31(11):1526-1535.Litton JK, Rugo HS, Ettl J, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation (supplementary appendix). N Engl J Med. 2018;379(8):753-763.Data on file. Pfizer Inc., New York, NY.TALZENNA® Summary of Product Characteristics. 

Legal Category: S1A 
Further information is available upon request

PP-TAL-IRL-0107 May 2024
Patient-reported outcomes with TALZENNA® Significantly longer PFS

Superior to chemotherapy in delaying disease progression4​​​​​​​

 See the data  Manageable safety profile 

AEs were manageable with a low discontinuation rate4​​​​​​​

 Review safety
TALZENNA Summary of Product Characteristics Product CharacteristicsLoading

Adverse events should be reported.

If you wish to make a medical information inquiry or report an adverse event please contact Pfizer on 1800 633 363 
or email Pfizer at [email protected] or visit www.PfizerMedicalInformation.ie

Report an adverse event to your national reporting system (HPRA Pharmacovigilance)

PfizerPro AccountPfizerPro Account

Please sign in or register to gain access to information relating to Pfizer medicines and vaccines, medical conditions, patient materials and services.

Sign in or RegisterRegisterAccountLog out

This site is intended only for healthcare professionals resident in the Republic of Ireland. If you are a member of the public wishing to access information on a specific medicine, please visit https://www.medicines.ie

 

This website is brought to you by Pfizer Healthcare Ireland Unlimited Company, The Watermarque Building, Ringsend Road, Dublin 4, Dublin, Ireland, D04 K7N3.  Registered in the Republic of Ireland No. 127002. Directors: D. Mangone (Managing), O. Gavan, D. Kennedy. Company Secretary: M.Byrne.  

 

Copyright © 2024 Pfizer Limited. All rights reserved.
 

PP-UNP-IRL-0891. February 2025
For Healthcare Professionals in the Republic of Ireland *

The information on this site is reserved exclusively for healthcare professionals resident in the Republic of Ireland and contains promotional content.

I confirm that I am a healthcare professional* resident in the Republic of Ireland.

If you select 'No', you will be redirected to Pfizer.ie, where you will be able to access information on Pfizer Healthcare Ireland Unlimited Company.

*The IPHA Code definition of a healthcare professional is a person of any of the following classes: (i) Registered medical practitioners (ii) Registered dentists (iii) Registered pharmacists (iv) Registered nurses

Terms of use

PP-UNP-IRL-0891. February 2025

Yes No
You are now leaving PfizerPro
You are now leaving PfizerPro Ireland. Links to external websites are provided as a resource to the viewer. This website is neither owned nor controlled by Pfizer. Pfizer accepts no responsibility for the content or services of the linked site.


PP-UNP-IRL-0891. February 2025