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Vyndaqel 61mg is indicated for the treatment of wild‑type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy
(ATTR-CM).1
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 of the SmPC for how to report adverse reactions.
In a retrospective cohort study of 382 patients with ATTR-CM, 69% (265 patients) had atrial fibrillation5 |
Reduced longitudinal strain with apical sparing should raise suspicion of ATTR-CM7,9
Illustrative representation.
In a study of patients with wATTR-CM, 46% had carpal tunnel syndrome10 |
Bilateral carpal tunnel syndrome and lumbar spinal stenosis
Biceps tendon rupture
Hip and knee arthroplasty
Nervous system dysfunction
The ESC Working Group recommends screening for ATTR-CM if LV wall thickness is ≥12 mm + the presence of ≥1 red flag or clinical scenario11
ECG1,19
CMR1,19
Echo1,19,20
Biomarkers1,11,19
Legal Category: S1A.Further information available upon request
Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
Adverse events should also be reported to Pfizer Medical Information on 1800 633 363
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PP-UNP-IRL-0176. January 2023