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AboutAbout ATTR-CMUrgencySuspectDetectDiagnostic flowchartAbout ATTR-PNUrgencyAwarenessPartnershipStudy DesignStudy DesignAbout ATTR-PNUrgencyAwarenessPartnershipEfficacy & SafetyPivotal efficacyLong-term survivalSubgroup analysisKey secondary endpointsEarly efficacy measuresSafety profileATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileDosingATTR-CM dosingATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileMOD/MOARole of TTRATTR-CM MODATTR-CM MOAATTR-PNATTR-PN MODATTR-PN MOASupport & ResourcesMaterialsVideosATTR-PNATTR-PN MODATTR-PN MOA

Vyndaqel 61mg is indicated for the treatment of wild‑type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy
(ATTR-CM).1

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 of the SmPC for how to report adverse reactions.

In pre-specified secondary and exploratory analyses from ATTR-ACT1,2 VYNDAQEL demonstrated early signs of treatment effect​​​​​​​

As early as 1 month, patients with ATTR-CM treated with VYNDAQEL (tafamidis meglumine) 80 mg demonstrated significantly greater TTR stabilization vs placebo (87.8% vs 3.5%), respectively; p<0.0001)2

As early as 6 months, VYNDAQEL demonstrated a significant reduction in decline in functional capacity (6MWT) vs placebo1

As early as 6 months, VYNDAQEL demonstrated a significant reduction in decline of quality of life (KCCQ-OS) vs placebo1

At first measurement, patients receiving VYNDAQEL showed smaller increases in NT-proBNP levels vs those receiving placebo (at 12 months)1

 ATTR-ACT study design 6MWT=6-minute walk test; ATTR-CM=transthyretin amyloid cardiomyopathy; KCCQ-OS=Kansas City Cardiomyopathy Questionnaire-Overall Summary; NT-proBNP=N-terminal pro-B-type natriuretic peptide; TTR=transthyretin cardiomyopathy. 
Explore More ATTR-CM dosing Learn More VYNDAQEL specifically targets TTR destabilization View VYNDAQEL Mechanism of Action
NEXT: ATTR-CM safety profile
References:Maurer MS, Schwartz JH, Gundapaneni B, et al; ATTR-ACT Study Investigators. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Engl J Med. 2018;379(11):1007-1016. doi:10.1056/NEJMoa1805689Damy T, Garcia-Pavia P, Hanna M, et al. Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study. Eur J Heart. Published online October 18, 2020. doi:10.1002/ejhf.2027
VYNDAQEL Prescribing InformationLoading
Efficacy and Safety Profile

Legal Category: S1A.Further information available upon request

PP-VYN-IRL-0181. December 2022

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Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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