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AboutAbout ATTR-CMUrgencySuspectDetectDiagnostic flowchartAbout ATTR-PNUrgencyAwarenessPartnershipStudy DesignStudy DesignAbout ATTR-PNUrgencyAwarenessPartnershipEfficacy & SafetyPivotal efficacyLong-term survivalSubgroup analysisKey secondary endpointsEarly efficacy measuresSafety profileATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileDosingATTR-CM dosingATTR-PNPivotal efficacyPivotal efficacy ALTLong-term efficacyMutations efficacyLong-term survivalSafety profileMOD/MOARole of TTRATTR-CM MODATTR-CM MOAATTR-PNATTR-PN MODATTR-PN MOASupport & ResourcesMaterialsVideosATTR-PNATTR-PN MODATTR-PN MOA

Vyndaqel 61mg is indicated for the treatment of wild‑type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy
(ATTR-CM).1

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 of the SmPC for how to report adverse reactions.

ATTR amyloidosis is caused by TTR protein destabilization1-4

The onset of disease pathogenesis occurs during TTR tetramer destabilization and is not due to the production of TTR itself2,3

The unstable tetramer dissociates into monomers2-4​​​​​​​​​​​​​​

Misfolded monomers aggregate into amyloid fibrils2-4

Amyloid fibrils accumulate in the heart, which can cause life-threatening conditions such as ATTR-CM2-4

See the mechanism of disease (MOD) of ATTR-CMATTR=transthyretin amyloidosis; ATTR-CM=transthyretin amyloid cardiomyopathy; TTR=transthyretin.
Explore More ATTR-CM identification and diagnosis Download Resources
NEXT: VYNDAQEL mechanism of action
References:Donnelly JP, Hanna M. Cardiac amyloidosis: an update on diagnosis and treatment. Cleve Clin J Med. 2017;84(12 Suppl 3):12-26.Judge DP, Heitner SB, Falk RH, et al. Transthyretin stabilization by AG10 in symptomatic transthyretin amyloid cardiomyopathy. J Am Coll Cardiol. 2019;74(3):285-295. doi:10.1016/j.jacc.2019.03.012Sekijima Y. Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. J Neurol Neurosurg Psychiatry. 2015;86(9):1036-1043. doi:10.1136/jnnp-2014-308724Coelho T, Merlini G, Bulawa CE, et al. Mechanisms of action and clinical application of tafamidis in hereditary transthyretin amyloidosis. Neurol Ther. 2016;5(1):1-25. doi:10.1007/s40120-016-0040-x
VYNDAQEL Prescribing InformationLoading
MOD/MOA

Legal Category: S1A.Further information available upon request

PP-VYN-IRL-0176. December 2022

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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