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Vyndaqel 61mg is indicated for the treatment of wild‑type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Refer to section 4.8 of the SmPC for how to report adverse reactions.
The onset of disease pathogenesis occurs during TTR tetramer destabilization and is not due to the production of TTR itself2,3
The unstable tetramer dissociates into monomers2-4
Misfolded monomers aggregate into amyloid fibrils2-4
Amyloid fibrils accumulate in the heart, which can cause life-threatening conditions such as ATTR-CM2-4
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PP-UNP-IRL-0176. January 2023