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Efficacy and SafetyClinical Efficacy RAORAL StrategyReal-World EvidenceORAL Surveillance and Integrated Safety SummaryClinical Efficacy PsAOPAL Clinical ProgrammeClinical Efficacy UCOCTAVE Study DesignOCTAVE Clinical ProgrammeSub GroupsPost-hoc AnalysesSafety and TolerabilitySafety Profile SummarySpecial Warnings & Precautions for UseAboutXELJANZ Mechanism of ActionDosing and AdministrationDosing in RA & PsADosingDosing in UCDosingSupport & ResourcesSupport & ResourcesMaterialsPrescribing InformationPrescribing Information
Sub GroupsXELJANZ demonstrates efficacy in patients who have previously failed tumour necrosis factor inhibitor (TNFi) agents1Remission in patients with and without prior TNFi failure during induction1

Regardless of prior TNFi use, XELJANZ was more effective than placebo at 10mg BID1

Central reading of endoscopic findings was used for eligibility and primary and key secondary efficacy endpoint analyses.1
In OCTAVE Induction 1, patients had a mean Total Mayo score of 9 at baseline (n=598). 51% had previously failed TNFi; 75% corticosteroids; 74% lmmunosuppressant therapy. Previous treatment failure was determined by the Investigator.
In OCTAVE Induction 2, patients had a mean Total Mayo score of 9 at baseline (n=541 ). 52% had previously failed TNFi; 71 % corticosteroids; 69% immunosuppressant therapy. Previous treatment failure was determined by the investigator.
BID=twice daily; TNFi=tumour necrosis factor inhibitor.

Remission of patients with and without prior TNFi failure during maintenance1

Regardless of prior TNFi use, XELJANZ was more effective than placebo in maintaining remission.

Central reading of endoscopic findings was used for eligibility and primary and key secondary efficacy endpoint analyses.1
Patients had a mean Total Mayo score of 3.3 at the baseline of OCTAVE Sustain (n=593). 45% of patients had previously failed TNFi; 75% corticosteroids; 70% immunosuppressant therapy.1
BID=twice daily; TNFi=tumour necrosis factor inhibitor.Explore more Do you want to learn more about the OCTAVE study design? Learn more

Please refer to the XELJANZ Summary of Product Characteristics for full prescribing information

References:Dubinsky MC et al. Poster presented at: World Congress of Gastroenterology at the American College of Gastroenterology Annual Scientific Meeting; October 13–18, 2017, Orlando, FL, USA.XELJANZ Summary of Product Characteristics.
Clinical Efficacy in UC
SAFETY

Learn more about the XELJANZ safety profile

 See safety profile summary
DOSING

Learn about dosing in UC

 See recommended dosing
MECHANISM OF ACTION

Find out more about how XELJANZ works

 See how XELJANZ works

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