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AboutAboutBroad CoverageIndicationsEfficacyEfficacyEfficacyLimited Treatment OptionsSafetySafetySafetyDosingDosingAdult DosingPaediatric Dosing
Adult Dosing

Consistent dosing across indications1

Recommended dose for adult patients with estimated CrCl ≥51 mL/min (refer to SmPC for full dosing information)*
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Type of
Infection
Dose of ZAVICEFTA (ceftazidime-avibactam)
Frequency

Infusion time
Duration of treatment
cIAI†‡ 2 g/0.5 g Every 8 hours 2 hours 5–14 days
cUTI, including pyelonephritis 2 g/0.5 g Every 8 hours 2 hours 5–10 days§
HAP, including VAP 2 g/0.5 g Every 8 hours 2 hours 7–14 days
Bacteraemia associated with, or suspected to be associated with, cIAI, cUTI or HAP/VAP 2 g/0.5 g Every 8 hours 2 hours In accordance with the site of infection
Infections due to aerobic Gram-negative organisms in patients with limited treatment options†‡ 2 g/0.5 g Every 8 hours 2 hours Guided by severity of infection, the pathogen(s) and patient’s clinical and bacteriological progress||
  • No dose adjustment required in the elderly, patients with mild renal impairment (estimated CrCl ≥51 to ≤80 mL/min) and those with hepatic impairment.1
The dose of ZAVICEFTA in adult patients with estimated CrCl ≤50 mL/min should be adjusted according to recommended doses. CrCl estimated in adults using the Cockcroft–Gault formula.To be used in combination with metronidazole when anaerobic pathogens are known or suspected to be contributing to the infectious process.To be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process.The total duration shown may include intravenous ZAVICEFTA followed by appropriate oral therapy.There is very limited experience with the use of ZAVICEFTA for more than 14 days.Prescribing information

Zavicefta® (avibactam sodium, ceftazidime pentahydrate)

Zavicefta® (avibactam sodium, ceftazidime pentahydrate) 2g/0.5g powder for concentrate for
solution for infusion
)

Abbreviations:cIAI, complicated intra-abdominal infection; CrCl, creatinine clearance; cUTI, complicated urinary tract infection; HAP, hospital-acquired pneumonia; SmPC, Summary of Product Characteristics; VAP, ventilator-associated pneumonia.References:ZAVICEFTA. Summary of Product Characteristics, 2022.
Dosing

Legal Category: S1A

Further information available upon request

PP-ZVA-IRL-0241. December 2022

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

Adverse events should also be reported to Pfizer Medical Information on 1800 633 363

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