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AboutInfliximabWhat is infliximabMechanism of actionBiosimilarsApprovalOverviewPosition statementsECCOEULARESPGHANDosing & SwitchingDosingIV dosingAdministration & storageIV administrationStorageSafety informationImportant safety informationSwitchingConsiderations for switchingSafety informationImportant safety informationSafety informationImportant safety informationClinical EvidenceRandomised controlled trial evidenceSummary: randomised controlled trial evidenceSupport & ResourcesMaterials
Infliximab: mechanism of action

The active substance in infliximab is a monoclonal antibody.1,2 A monoclonal antibody is an antibody (a type of protein) which recognises and binds to a specific structure (called an antigen) in the body1,2

The antigen that infliximab recognises is the cytokine (a messenger protein) tumour necrosis factor alpha (TNF-ɑ)1,2

Infliximab is a chimeric antibody, where the antigen-binding portion is of murine origin, whereas the constant region is of human origin3,4

TNF-alpha is involved in driving inflammation and is found at high levels in patients with the immune-mediated inflammatory diseases that infliximab is used to treat. By blocking TNF-ɑ, infliximab improves inflammation and other symptoms of those diseases1,2

Watch our video to learn how infliximab inhibits the functional activity of TNF-ɑ

Please refer to the SmPC before prescribing INFLECTRA®. Please click here to be directed to the SmPC.

References:European Public Assessment Report – Summary for the public: Remicade™. November 2018. Available at: https://www.ema.europa.eu/en/documents/overview/remicade-epar-summary-public_en.pdf. Accessed May 2023.European Public Assessment Report – Summary for the public: INFLECTRA®. September 2013. Available at: https://www.ema.europa.eu/en/documents/overview/inflectra-epar-summary-public_en.pdf. Accessed May 2023.European Public Assessment Report: Remicade™. 19 January 2012. Available at: https://www.ema.europa.eu/en/documents/variation-report/remicade-h-c-240-ii-0150-epar-assessment-report-variation_en.pdf. Accessed May 2023.European Public Assessment Report: INFLECTRA®. 27 June 2013. Available at: http://www.ema.europa.eu/docs/en_GB/document_ library/EPAR_-_Public_assessment_report/human/002778/ WC500151490.pdf. Accessed May 2023.
Infliximab
INFLECTRA® dosing

Read about dosing and administration of INFLECTRA®

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PP-IFA-IRL-0145 May 2023

Adverse events should be reported. Report an adverse event to your national reporting system (HPRA Pharmacovigilance)
 

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