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AboutInfliximabWhat is infliximabMechanism of actionBiosimilarsApprovalOverviewPosition statementsECCOEULARESPGHANDosing & SwitchingDosingIV dosingAdministration & storageIV administrationStorageSafety informationImportant safety informationSwitchingConsiderations for switchingSafety informationImportant safety informationSafety informationImportant safety informationClinical EvidenceRandomised controlled trial evidenceSummary: randomised controlled trial evidenceSupport & ResourcesMaterials
What is infliximab?Infliximab infusion therapy is an established treatment for many inflammatory diseases1-7Infliximab has more than 20 years of experience as an infusion therapy1

Clinical efficacy of infliximab infusion therapy has been demonstrated across all adult and paediatric indications†1,6,11-15

Appropriate use of infliximab infusion therapy is supported by clinical guidelines in CD/UC, paediatric CD/UC, RA, PsA and AS13, 16-22

Evidence from a range of analyses, including randomised controlled trials, registry studies, post-marketing surveillance studies, and retrospective comparisons.Guidelines of the Assessment of Spondyloarthritis International Society (AS), the European Crohn’s and Colitis Organisation (CD, UC), the European League Against Rheumatism (AS, PsA, RA), and the European Society for Paediatric Gastroenterology Hepatology and Nutrition (paediatric CD, paediatric UC).AS, Ankylosing spondylitis; CD, Crohn’s disease; PsA, Psoriatic arthritis; PsO, Psoriasis; RA, Rheumatoid arthritis; TNFi, Tumour necrosis factor inhibitor; UC, Ulcerative colitis.

Please refer to the INFLECTRA® Summary of Product Characteristics for full prescribing information

References:Melsheimer R, et al. Biologics 2019;13:139-78. Danese S, et al. Aliment Pharmacol Ther 2011;33:857-69.Moss AC. Gastroenterol Rep 2015;3(1):63-8. Guariso G, Gasparetto M. World J Gastroenterol 2017;23:5469-85.Aardoom MA, et al. Int J Mol Sci 2019;20:2529. Doi: 10.3390/ijms20102529.Smolen JS, Emery P. Arthritis Res Ther 2011;13(Suppl 1):S2.Remicade™ Summary of Product Characteristics.Medscape. FDA Approvals. September 2005. Available at: https://www.medscape.com/viewarticle/513282. Accessed May 2023. EMA. Remicade™ Scientific Discussion. January 2006. Available at: https://www.ema.europa.eu/en/documents/scientific-discussion-variation/remicade-h-c-240-ii-0065-epar-scientific-discussion-variation_en.pdf. Accessed May 2023.Centocor, Inc. [Public Release: 7 November 2007]. Available at: https://www.fdanews.com/articles/100766-remicade-becomes-first-anti-tnf-biologic-therapy-to-treat-1-million-patients.Dave M, Loftus EV. Gastroenterol Hepatol (N Y) 2012;8(1):29-38.Singh S, et al. Clin Gastroenterol Hepatol 2017;15:1218-25.Gomollon F, et al. J Crohns Colitis 2017;11(1):3-25.Hyams J, et al. Gastroenterology 2007;132(3):863-73.Hyams J, et al. Clin Gastroenterol Hepatol 2012;10(4):391-9.Harbord M, et al. J Crohns Colitis 2017;769-84. [Epub ahead of print].Turner D, et al. jpgN 2018;67:257-91.Turner D, et al. jpgN 2018;67:292-310.Ruemmele FM, et al. J Crohns Colitis 2014;8:1179-207.Smolen JS, et al. Ann Rheum Dis 2020;0:1-15.Gossec L, et al. Ann Rheum Dis 2016;75:499-510.van der Heijde D, et al. Ann Rheum Dis 2017;76:978-91. 
Infliximab
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