Data described here are reflective of the CROWN trial, a Phase 3 study of LORVIQUA vs crizotinib in patients with previously untreated, ALK-positive, locally advanced or metastatic NSCLC.1
The most common adverse reactions are reported below.
Adverse reaction | Any grade | Grades 3 and 4 |
---|---|---|
Hypercholesterolaemiab | 70.5% | 16.1% |
Hypertriglyceridaemiab | 63.8% | 20.1% |
Oedemab | 55.0% | 4.0% |
Weight increased | 38.3% | 16.8% |
Peripheral neuropathyb | 33.6% | 2.0% |
Cognitive effectsb,c | 21.5% | 2.0% |
Diarrhoea | 21.5% | 1.3% |
Anemia | 19.5% | 2.7% |
Fatigueb | 19.5% | 1.3% |
Hypertension | 18.1% | 10.1% |
Vision disorderb | 18.1% | 0.0% |
Increased ALT level | 17.4% | 2.7% |
Constipation | 17.4% | 0.0% |
Mood effectsb,d | 16.1% | 1.3% |
Nausea | 14.8% | 0.7% |
Increased AST level | 14.1% | 2.0% |
Vomiting | 12.8% | 0.7% |
Hyperlipidemia | 10.7% | 2.0% |
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PP-UNP-IRL-0784. June 2024