Data described here are reflective of the Phase 1/2 study of LORVIQUA in patients with previously treated ALK-positive, advanced or metastatic NSCLC.1
The most common adverse reactions are reported below.
Adverse reaction | Any grade | Grades 3 and 4 |
---|---|---|
Hypercholesterolaemiaa | 81.5% | 15.6% |
Hypertriglyceridaemiaa | 60.4% | 15.6% |
Oedemaa | 43.3% | 2.2% |
Peripheral neuropathya | 29.8% | 1.8% |
Weight increased | 18.2% | 1.8% |
Cognitive effectsa | 17.8% | 1.1% |
Mood effectsa | 14.9% | 0.7% |
Fatiguea | 13.1% | 0.4% |
Diarrhoea | 10.5% | 0.4% |
Arthralgia | 10.2% | 0.0% |
AST increased | 10.2% | 0.4% |
Adapted from Solomon NJ, et al. Lancet Oncol. 2018.
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