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ATTR-CMATTR-CMATTR-CM HomeAbout ATTR-CMMechanism of DiseaseWild-Type ATTR-CMHereditary ATTR-CMSuspect ATTR-CMDetect ATTR-CMResourcesMaterialsVideosTreatment Option
Transthyretin amyloid cardiomyopathy (ATTR-CM)

​​​​​​​ATTR-CM is an underdiagnosed, progressive, and infiltrative disease that can often be overlooked as a cause of heart failure.1,2

Early diagnosis and treatment of ATTR-CM are critical to extend life3

Prognosis worsens rapidly with continued amyloid deposition, resulting in advancing organ dysfunction, significant reduction in quality of life, and, ultimately, death.1,4

Heart failure with preserved ejection fraction, especially in patients older than 60 years, warrants evaluation by a cardiologist.5,6

Untreated patients have a median survival of ~2 to 3.5 years once diagnosed with ATTR-CM.4

Frequently asked questions about ATTR-CM Why does ATTR-CM matter to my practice and my patients? What are the ATTR-CM signs I should be looking for? What are the latest diagnostic techniques?
  • Noninvasive nuclear scintigraphy. Read more
  • Review the ATTR-CM diagnostic flowchart. View now
  • Multisocietal Expert Consensus Recommendations. Learn more
  • Diagnosing and collaborating with nuclear scintigraphy. Watch now
About ATTR-CM > LoadingReferences:Witteles RM, Bokhari S, Damy T, et al. Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Heart Fail. 2019;7(8):709-716. doi:10.1016/j.jchf.2019.04.010Maurer MS, Hanna M, Grogan M, et al. Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68(2):161-172. doi:10.1016/j.jacc.2016.03.596Elliott P, Drachman BM, Gottlieb SS, et al. Long-term survival with tafamidis in patients with transthyretin amyloid cardiomyopathy. Circ Heart Fail. 2022;15:e008193. doi:10.1161/CIRCHEARTFAILURE.120.008193 Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation. 2017;135(14):1357-1377. doi:10.1161/CIRCULATIONAHA.116.024438 Garcia-Pavia P, Rapezzi C, Adler Y, et al. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021;42(16):1554-1568. doi:10.1093/eurheartj/ehab072Dorbala S, Ando Y, Bokhari S, et al. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2—evidence base and standardized methods of imaging. J Nucl Cardiol. 2019;26(6):2065-2123. doi:10.1007/s12350-019-01760-6. Addendum: J Nucl Cardiol. Published online July 1, 2021. doi:10.1007/s12350-020-02455-z
ATTR-CM Discover more about ATTR-CM What imaging modalities help raise suspicion of ATTR-CM?

Gain a deeper understanding of echocardiography and cardiac magnetic resonance (CMR).

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Detect ATTR-CM noninvasively with nuclear scintigraphy6

Review the evidence and consensus recommendations for diagnosis.

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The CARE program

The CARE program features a variety of educational materials for cardiologists as well as content intended to educate patients about ATTR-CM and aid in the process of referral to a specialist.

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Sign up for alerts to help you suspect and detect ATTR-CM. Sign upLoading
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