Neuroprotective effects have been shown in both the peripheral nervous system (PNS) and the central nervous system (CNS) in animal and clinical studies2
Protection against neurodegeneration and Alzheimer disease in a mouse model2
In ATTR-CM, a TTR gene mutation or age-related changes destabilise the protein tetramers, which separate into monomers and then misfold and aggregate into amyloid fibrils that deposit in the heart and other organs over time.2,4
Because amyloid fibrils can deposit in different parts of the body, including the heart and nerves, some patients may present with a mixed phenotype, namely, symptoms of both cardiomyopathy and polyneuropathy.2,5
Suspicion of cardiac involvement should prompt immediate cardiac evaluation to assess for ATTR-CM.6
Gain a deeper understanding of echocardiography and cardiac magnetic resonance (CMR).
Review the evidence and consensus recommendations for diagnosis.
Sign up for alerts to help you suspect and detect ATTR-CM.
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